New patterns of HIV-1 resistance during HAART
نویسندگان
چکیده
منابع مشابه
Criteria for Annihilation of HIV-1 During HAART Therapy
HAART therapy of HIV-1 induced AIDS is modeled by a system of non-linear deterministic differential equations. The clinically plausible patho-physiological equations depict the dynamics of uninfected CD4 T cells (x1), HIV-1 infected CD4+ T cells (x2), HIV-1 virions in the blood plasma (x3), HIV-1 specific CD8 T cells (x4), and the concentration of HAART drug molecules (x5). The criteria for the...
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Recent studies on patients with a history of pre-HAART drug resistance, but currently on a successful regimen, provided new insights into the dynamics of the latent cellular viral reservoir. Results indicated that the latent reservoir is an archive, composed of a mixture of wild-type and drug-resistant strains. The studies showed that, even after years of successful HAART, the wild-type viral s...
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OBJECTIVES To understand the dynamic viral evolution observed during failure on raltegravir-containing regimens, we studied the genotypic and phenotypic patterns of resistance to raltegravir and the residual replication capacity (rRC) of HIV-1 variants selected in vivo. METHODS Clonal genotypic analyses were performed on sequential HIV-1 integrase sequences amplified from 11 failing patients ...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2003
ISSN: 1198-743X
DOI: 10.1046/j.1469-0691.2003.00730.x